Albumin/Globulin (A/G) Ratio Calculator

Get your A/G ratio from albumin and total protein.

How it is calculated

Blood tests report albumin and total protein but not globulin, so the tool derives it: Globulin = TP − Alb and A/G ratio = Alb / Globulin. Alb is serum albumin and TP is total protein, both in g/dL. The ratio is shown with two decimals and globulin in g/dL with one decimal. The tool gives no result when albumin is zero or negative, when total protein is equal to or smaller than albumin (globulin would be zero or negative), or when the values are implausible for g/dL: albumin above 10 or total protein above 20. It does not convert units and does not label the ratio as low or normal.

Worked example

A panel shows albumin 4.2 g/dL and total protein 7.0 g/dL. Globulin is the part of total protein that is not albumin: 7.0 − 4.2 = 2.8 g/dL. The A/G ratio is 4.2 / 2.8 = 1.50, so albumin is one and a half times the globulin. The tool then reports globulin as 2.8 g/dL. Whether 1.50 is in range depends on the reference interval printed by your laboratory.

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Common mistakes

  • Entering values in g/L (42 and 70). The tool expects g/dL and gives no result because 42 is far above the accepted albumin limit of 10; divide g/L values by 10 first.
  • Typing globulin in the total protein field. Total protein must be larger than albumin, so a small globulin value gives no result.
  • Swapping albumin and total protein. If albumin is larger than total protein, or the two are equal, globulin would be zero or negative and nothing is shown.
  • Using values that are almost equal. With albumin 4.2 and total protein 4.21, globulin rounds to 0.0 g/dL and the ratio jumps to 420.00, which is a rounding artefact, not a finding.
  • Judging the ratio on its own. A low or high ratio does not say whether albumin or globulin is the cause, so look at both numbers and discuss them with a clinician.

About this calculator

The albumin/globulin (A/G) ratio compares the two main protein fractions in blood: albumin, made almost entirely by the liver, and globulin, the combined weight of immune, transport and enzyme proteins (calculated as total protein minus albumin). It is a simple division — albumin divided by globulin — but the number carries real diagnostic weight because the two fractions tend to move in opposite directions in disease.

A normal A/G ratio is roughly 1.1 to 2.5, meaning albumin is typically somewhat higher than globulin. A low ratio can point to conditions that either drop albumin (liver cirrhosis, nephrotic syndrome, malnutrition) or raise globulin (chronic inflammation, autoimmune disease, and especially multiple myeloma, where a monoclonal antibody spike pushes globulin up sharply). A high ratio is less common but can appear with certain immune deficiencies or high-dose corticosteroid use.

Clinicians order this as part of a comprehensive metabolic panel or a dedicated total-protein panel, using the A/G ratio alongside liver enzymes and kidney function tests to narrow down whether an abnormal total protein result is coming from the liver, the kidneys, or the immune system.

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