Vancomycin AUC Dosing Calculator

How it is calculated

The tool uses a one-line clearance model. Vancomycin clearance is estimated as CL (L/h) = 0.75 × CrCl × 0.06, where CrCl is creatinine clearance in mL/min (the factor 0.06 converts mL/min to L/h, and 0.75 is the fixed share of creatinine clearance assumed to apply to vancomycin). At steady state AUC24 = daily dose / CL, so daily dose (mg) = target AUC24 (mg·h/L) × CL. Half of that is shown as the dose every 12 hours, rounded to the nearest 250 mg. Both inputs must be above zero. There is no weight, age, loading dose or measured level in the model, so this is a rough starting estimate and not a dosing instruction. Local protocols decide the real regimen.

Common mistakes

• Entering creatinine clearance in mL/s, in L/h or as the serum creatinine itself. The model expects CrCl in mL/min, so 90 means 90 mL/min.
• Using the 12-hour dose as a final order. It is rounded to 250 mg and based on a single fixed clearance relation, so it needs adjustment from measured levels and the patient's condition.
• Mixing up the target. The AUC24 is the area over a full day in mg·h/L; entering a trough concentration or a 12-hour area will give a wrong daily dose.
• Expecting the tool to include a loading dose, weight-based dosing or a dosing-interval choice. It returns only a daily dose, a 12-hourly share and the clearance.
• Using a creatinine clearance from a patient whose kidney function is changing fast. Steady state is assumed, so in unstable kidney function the estimate can be misleading.